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ROLE OF MENINGEAL FIBROBLASTS AND MAST CELLS
IN OPIATE INDUCED INFLAMMATORY MASSES

Tony L. Yaksh, Ph.D.
Department of Anesthesiology, University of California,
San Diego, La Jolla, CA, USA

Spinal opiates yield a potent naloxone reversible analgesia. The first report of continuous
intrathecal morphine delivery to manage chronic pain was in 1978. (Onofrio, et al, 1978).
Aside from anticipated opiate effects, no evidence of untoward effects on spinal function
were reported. Beginning in 1991, numerous clinical case series describe patients receiving
intrathecal morphine infusion who present with neurologic signs secondary to a local
compressive lesion. Retrospective data indicate an overall incidence of 0.1% although
estimates in limited populations have been as high as 43% (Deer et al., 2017c).

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